Aspirin Before Cardiac Surgery Beneficial
Preoperative aspirin therapy was associated with a host of beneficial effects spanning several organ systems, according to a large observational study.
"This study provides new evidence that preoperative aspirin therapy (versus no preoperative aspirin) is associated with a significant decrease in risk of 30 day mortality (3.5% versus 6.5%), renal failure (3.7% versus 7.1%), dialysis required (1.9% versus 3.6%), ICU stay (average 107.2 hours versus 136.1), and a composite outcome -- MACE (8.7% versus 10.8%); and is not associated with increased risk of readmissions (14.5% versus 12.8%)," Jianzhong Sun, MD, PhD, of Thomas Jefferson University in Philadelphia, and colleagues wrote in Annals of Surgery.
Moreover, aspirin was beneficial even though patients taking preoperative aspirin were significantly older and had more comorbidities than those not taking aspirin.
Taken together, preoperative aspirin seems to have efficacy in the face of the "most important confounding factors -- comorbidities" in these high-risk patients, they said.