Surgery Tops Drugs For Resistant Epilepsy

Mon, 03/12/2012 - 7:30am
Todd Neale

Early surgical intervention appears to be superior to continued drug therapy for patients with drug-resistant temporal lobe epilepsy, researchers found.

In a trial stopped well short of its enrollment goal, patients who underwent surgery were significantly more likely to be seizure free during the second year of follow-up (73 percent versus 0 percent, P<0.001), according to Jerome Engel Jr., MD, PhD, of the University of California Los Angeles (UCLA), and colleagues.

They also had greater gains in quality of life -- though the difference fell short of statistical significance (P=0.08) -- but a higher rate of memory decline, the researchers reported in the March 7 issue of the Journal of the American Medical Association.

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