Wide Surgical Margins Best For DCIS

Fri, 03/23/2012 - 5:39am
Crystal Phend

Lumpectomy for ductal carcinoma in situ (DCIS) should aim for wide margins to keep recurrence risk low even if the woman is getting radiotherapy, according to the conclusions of a heavily criticized meta-analysis.

A negative margin of at least 10 mm cut ipsilateral recurrence risk by a significant 54 percent compared with getting a negative margin of only greater than 2 mm (odds ratio 0.46, 95 percent credible interval 0.29 to 0.69), Shi-Yi Wang, MD, of the University of Minnesota School of Public Health in Minneapolis, and colleagues found.

The probability that the best threshold for an acceptable margin was over 10 mm was 96 percent, the group reported in the April 4 issue of the Journal of the National Cancer Institute.

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