Cheaper Drug Cuts Surgery Site Infections
The use of povidone-iodine nasal solution immediately before surgery should be considered as an alternative option to five days use of mupirocin ointment to prevent Staphylococcus aureus and other deep surgical site infections.
After 3 months follow-up in the intent-to-treat analysis, deep surgical site infections occurred in 14 patients on mupirocin and in six patients on povidone-iodine, said Michael Phillips, MD, clinical assistant professor of medicine at New York University Langone Medical Center, showing that the povidone-iodine solution was at least equally effective in infection control as standard of care mupirocin (P=0.07).
In the per protocol analysis, the numerical differences were similar to those in the intent-to-treat analysis. The researchers observed 13 infections in the mupirocin patients and five infections among the povidone-iodine patients.