New Alternative For Pancreatic Biopsy

Mon, 01/18/2010 - 6:57am

It is reasonable to obtain a histological diagnosis before treating patients who have pancreatic masses and are unsuitable or unwilling to undergo surgery. As the pancreas is a deep-seated organ surrounded by other vital structures, it is a challenge for the physician to obtain an adequate specimen for histological examination.

Endoscopic ultrasound-guided biopsy of pancreatic masses has proven to be a safe and effective method. However, if the hospital has no such facilities or patients are unwilling or intolerant of the procedure, computed tomography (CT)-guided biopsy is now a gaining acceptance as an alternative method.

A research article published in the World Journal of Gastroenterology addresses this question. A research team from Taiwan reviewed a collection of CT-guided biopsies in patients with pancreas mass, of whom 71 percent had a direct path to the mass without passing through a major organ.

Their results showed tumor tissues were obtained in nine pancreatic biopsies, and histologic specimens for diagnosis were obtained in all cases. An immediate imaging study and clinical follow-up detected neither hemorrhage nor peritonitis. No delayed procedure-related complication was seen during the survival period of all patients.

This resulted in a conclusion that it is feasible to perform transgastric biopsy of a pancreatic lesion using a large needle.


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