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The Role Of Blood Flow In Preventing Chronic Kidney Disease

Tue, 06/15/2010 - 5:59am

Interrupting the blood flow for more than 20 to 25 minutes during kidney cancer surgery leads to a greater risk of patients developing chronic kidney disease, a Mayo Clinic and Cleveland Clinic collaborative research team has found. The study was published in the journal European Urology.

For the retrospective study, researchers analyzed outcomes of 362 patients with only one kidney who underwent surgery for renal cortical tumors at Mayo Clinic and Cleveland Clinic between 1990 and 2008. Using a technique called warm ischemia, surgeons kept the patient's kidneys at body temperature during the partial nephrectomy. Ischemia involves cutting off the blood supply to the kidney with clamps in order to control bleeding and to keep blood from obscuring the surgeon's view of the kidney. It also allows for precise closure of the urine collecting system and the surgical opening. The median ischemia time was 21 minutes in the study and the median age of patients was 62 years.

Ischemia can cause tissue damage from a lack of oxygen and nutrients. Researchers found that each additional minute of warm ischemia is associated with a five to six percent increase in the odds of developing acute renal failure or reduced kidney functioning, and is associated with a six percent increased risk of new onset Stage IV chronic kidney disease during long-term follow-up.

According to R. Houston Thompson, M.D., a Mayo Clinic urologist and the study's primary investigator, “these results suggest that every minute counts when the renal arteries and veins are clamped. When planning for the surgery, surgeons should make efforts to minimize ischemia time, especially in situations where a person only has one kidney.

“Historically, 30 minutes was considered the maximum safe duration of warm ischemia during partial nephrectomy, and other retrospective clinical studies have suggested that warm ischemia for 40 to 55 minutes is safe. However, these studies included patients with two kidneys, which could mask the true effects of ischemia on renal function.

“Because each additional minute of warm ischemia invites the risk for chronic kidney problems, if longer ischemic times are unavoidable, techniques such as ice slush (cold ischemia) should be considered,” he concludes.

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