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Anti-Clot Compound Again Shows Bleeding Risk

Tue, 02/07/2012 - 5:26am

WHITEHOUSE STATION, N.J. (AP) — An experimental anti-clotting drug that Merck & Co. is developing increased risk of bleeding internally in a study, the second time it's shown that dangerous side effect.

Merck says the top-line results from a study called TRA-2P show vorapaxar, when added to standard anticlotting therapy, reduces risk of heart attack, stroke, death from heart disease or emergency heart surgery.

But the company says there was a significant increase in bleeding, including bleeding inside the skull. That intracranial bleeding was less common in patients who had not previously had a stroke.

A year ago, Merck halted another study because of the same bleeding problem.

Merck says it will present detailed results from the latest study at a March medical conference.

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