EVICEL Fibrin Sealant is the first fibrin sealant to be indicated as an adjunct to hemostasis for use in patients undergoing surgery, when control of bleeding by standard surgical techniques is ineffective or impractical. EVICEL is the only all-human plasma-derived fibrin sealant commercially available in the United States. It does not contain aprotinin, which has been associated with adverse health effects. The fibrin sealant is easy to use and readily available for time-sensitive needs in the operating room. The product is sold as a frozen liquid and requires less than one minute preparation time after thawing.