InQu Bone Graft Extender and Substitute from ISTO Technologies combines the structural and biological attributes of poly(lactide-co-glycolide) (PLGA) and hyaluronic acid (HyA), two biomaterials with a long history of safe and effective clinical use. InQu's unique scaffold creates a product with a microenvironment that is both biocompatible and conducive to new bone formation. PLGA imparts the three-dimensional structure to InQu, and provides a reliable resorption rate at the site of implantation. HyA is reported to play a critical role in tissue regeneration and repair (1). In addition, HyA is known to aid essential early events in bone formation by promoting the migration, proliferation, and differentiation of osteogenic cells (2-4).
InQu is available in Paste Mix (2.5, 5, and 10 cc), Matrix (5x5 cm and 5x10 cm), or Granules (10 and 30 cc). InQu can be prepared using a pre-measured quantity of saline or equivalent amounts of an appropriate patient-derived bodily fluid such as blood or bone marrow aspirate.
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