The reduction in blood pressure following renal artery denervation is projected to significantly decrease long-term cardiovascular events, a modeling study found.

The 10-year relative risk (RR) reduction for cardiovascular events was highest in 40-year-olds and lowest in 70-year-olds, while the absolute event reduction was highest in 70-year-olds and lowest in 40-year-olds, according to Jan Pietzsch, PhD, from healthcare economics consulting firm Wing Tech of Menlo Park, Calif., and colleagues.

For example, a more than 40% RR reduction of heart attack was projected over 10 years for patients at age 40 with an index systolic blood pressure (SBP) over 190 mmHg, which also translated into a 1% absolute event reduction.

In contrast, 70-year-old patients with an index SBP over 190 mmHg had a 25% RR reduction of heart attack, which translated into an 8% absolute event reduction over 10 years, Pietzsch reported at the annual meeting of the Society for Cardiovascular Angiography and Interventions.

"We found clinically meaningful reductions across the board in terms of absolute and relative reductions of clinical events in all three age groups," Pietzsch told MedPage Today during a phone interview.

Besides heart attack, the model also took into account all coronary heart disease (CHD), stroke, heart failure (HF), and end-stage renal disease (ESRD).

Other 10-year RR risk reductions for ages 40, 55, and 70 and SBP 190 mmHg include:

Continue reading...